| 07 Nov 2021 | Regular | Pennsylvania State University, Altoona | W&L | 96 - 93 |
| 13 Nov 2021 | Regular | Juniata | Pennsylvania State University, Altoona | 65 - 67 |
| 16 Nov 2021 | Regular | W & J College | Pennsylvania State University, Altoona | 103 - 102 |
| 19 Nov 2021 | Regular | Penn St. Abington | Pennsylvania State University, Altoona | 74 - 81 |
| 20 Nov 2021 | Regular | Cairn | Pennsylvania State University, Altoona | 58 - 77 |
| 28 Nov 2021 | AMCC | Alfred State | Pennsylvania State University, Altoona | 95 - 106 |
| 01 Dec 2021 | AMCC | Pennsylvania State University, Altoona | La Roche | 88 - 72 |
| 04 Dec 2021 | AMCC | Medaille | Pennsylvania State University, Altoona | 69 - 95 |
| 08 Dec 2021 | AMCC | Mt. Aloysius | Pennsylvania State University, Altoona | 81 - 84 |
| 11 Dec 2021 | AMCC | Pennsylvania State University, Altoona | Pitt.-Bradford | 112 - 85 |
| 19 Dec 2021 | Regular | Pennsylvania State University, Altoona | Piedmont | 77 - 75 |
| 20 Dec 2021 | Regular | SUNY Brockport | Pennsylvania State University, Altoona | 74 - 62 |
| 30 Dec 2021 | Regular | Pennsylvania State University, Altoona | Misericordia | cancelled |
| 08 Jan 2022 | AMCC | Pennsylvania State University, Altoona | Hilbert | 108 - 81 |
| 12 Jan 2022 | Regular | Pennsylvania State University, Altoona | Salisbury | 81 - 102 |
| 15 Jan 2022 | AMCC | Pennsylvania State University, Altoona | Penn St. Behrend | 71 - 88 |
| 19 Jan 2022 | AMCC | Pitt.-Greensburg | Pennsylvania State University, Altoona | 73 - 94 |
| 22 Jan 2022 | AMCC | Pennsylvania State University, Altoona | Medaille | 87 - 88 |
| 26 Jan 2022 | AMCC | Pennsylvania State University, Altoona | Mt. Aloysius | 87 - 67 |
| 29 Jan 2022 | AMCC | Pitt.-Bradford | Pennsylvania State University, Altoona | 79 - 97 |
| 02 Feb 2022 | AMCC | La Roche | Pennsylvania State University, Altoona | 87 - 96 |
| 05 Feb 2022 | AMCC | Pennsylvania State University, Altoona | Alfred State | 95 - 89 |
| 09 Feb 2022 | AMCC | Pennsylvania State University, Altoona | Pitt.-Greensburg | 98 - 79 |
| 12 Feb 2022 | AMCC | Hilbert | Pennsylvania State University, Altoona | 66 - 82 |
| 19 Feb 2022 | AMCC | Penn St. Behrend | Pennsylvania State University, Altoona | 63 - 60 |
| 25 Feb 2022 | Tournament | Pennsylvania State University, Altoona | La Roche | 63 - 95 |
| 04 Mar 2022 | Non conference | Pennsylvania State University, Altoona | Merchant Marine | 85 - 73 |
| 05 Mar 2022 | Non conference | William Paterson | Pennsylvania State University, Altoona | 81 - 86 |