| 16 Nov 2021 | Regular | Indiana University-Purdue University Fort Wayne | Austin Peay | 65 - 60 |
| 19 Nov 2021 | Regular | Minnesota | Indiana University-Purdue University Fort Wayne | 78 - 49 |
| 26 Nov 2021 | Regular | Indiana University-Purdue University Fort Wayne | SE Louisiana | 74 - 66 |
| 27 Nov 2021 | Regular | W Michigan | Indiana University-Purdue University Fort Wayne | 93 - 85 OT |
| 28 Nov 2021 | Regular | FGCU | Indiana University-Purdue University Fort Wayne | 85 - 78 |
| 02 Dec 2021 | Horizon | Indiana University-Purdue University Fort Wayne | Wright State | 73 - 86 |
| 04 Dec 2021 | Horizon | Indiana University-Purdue University Fort Wayne | N Kentucky | 71 - 57 |
| 08 Dec 2021 | Regular | SIU Edwardsville | Indiana University-Purdue University Fort Wayne | 80 - 59 |
| 11 Dec 2021 | Regular | Indiana University-Purdue University Fort Wayne | SE Missouri St | 78 - 65 |
| 21 Dec 2021 | Regular | Michigan | Indiana University-Purdue University Fort Wayne | - |
| 30 Dec 2021 | Horizon | Cleveland St | Indiana University-Purdue University Fort Wayne | 90 - 81 |
| 01 Jan 2022 | Horizon | IUPUI | Indiana University-Purdue University Fort Wayne | - |
| 05 Jan 2022 | Horizon | Cleveland St | Indiana University-Purdue University Fort Wayne | 65 - 58 |
| 07 Jan 2022 | Horizon | Youngstown St | Indiana University-Purdue University Fort Wayne | 61 - 71 |
| 09 Jan 2022 | Horizon | Robert Morris | Indiana University-Purdue University Fort Wayne | 70 - 76 |
| 13 Jan 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Detroit Mercy | 62 - 60 |
| 15 Jan 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Oakland | 68 - 76 |
| 21 Jan 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Robert Morris | 86 - 62 |
| 23 Jan 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Youngstown St | 82 - 71 |
| 28 Jan 2022 | Horizon | N Kentucky | Indiana University-Purdue University Fort Wayne | 59 - 49 |
| 30 Jan 2022 | Horizon | Wright State | Indiana University-Purdue University Fort Wayne | 75 - 63 |
| 04 Feb 2022 | Horizon | Indiana University-Purdue University Fort Wayne | UW Milwaukee | 70 - 60 |
| 06 Feb 2022 | Horizon | Indiana University-Purdue University Fort Wayne | UW Green Bay | 71 - 55 |
| 10 Feb 2022 | Horizon | Indiana University-Purdue University Fort Wayne | IUPUI | 72 - 57 |
| 12 Feb 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Illinois-Chicago | 73 - 66 |
| 14 Feb 2022 | Horizon | Indiana University-Purdue University Fort Wayne | Cleveland St | 102 - 98 OT |
| 18 Feb 2022 | Horizon | UW Green Bay | Indiana University-Purdue University Fort Wayne | 55 - 74 |
| 20 Feb 2022 | Horizon | UW Milwaukee | Indiana University-Purdue University Fort Wayne | 71 - 81 |
| 24 Feb 2022 | Horizon | Oakland | Indiana University-Purdue University Fort Wayne | 70 - 81 |
| 26 Feb 2022 | Horizon | Detroit Mercy | Indiana University-Purdue University Fort Wayne | 78 - 81 |
| 03 Mar 2022 | Tournament | Indiana University-Purdue University Fort Wayne | Illinois-Chicago | 78 - 72 |
| 07 Mar 2022 | Tournament | Indiana University-Purdue University Fort Wayne | N Kentucky | 43 - 57 |
| 19 Mar 2022 | CBI 1/8 final | Indiana University-Purdue University Fort Wayne | Drake | 65 - 87 |